The day before the researcher Dr. Zheng Mingbin College of medicine of Guangdong Medical University and Chinese Academy of Sciences, Shenzhen Institute of advanced technology Cai Lintao cooperation, in the homologous drug loaded nano to make new breakthroughs and accurate visualization for cancer treatment, the development of "new treatment of cancer, cancer research recently in the field of Nanotechnology" ACS Nano "top journals published.
Zheng Mingbin, the research team constructed the encapsulation of indocyanine green (ICG) - cancer cell membrane biomimetic polymer nanoparticles (ICNPs), and applied to the diagnosis and treatment of breast cancer by homologous MCF-7. The expression of adhesion molecules on the membrane of cancer cells, such as epithelial cell adhesion molecules, N-cadherin, galectin, through receptor - ligand binding form to cancer cells each other "navigation" and "anchor". Nano particles wear vest to cancer cell adhesion molecule recognition MCF-7 adhesion cancer cell membrane, to avoid the effect of chemical modification to the target complex and potentially uncontrollable factors.
"After the cancer cell membrane was coated, nanoparticles not only disguise themselves, reduce the rejection of the liver and kidney, and ultimately achieve the target enrichment of MCF-7 tumor. Under the guidance of fluorescence and photoacoustic imaging, the local temperature of the tumor site was precisely controlled by the near infrared laser pointer excitation." Zheng Mingbin said.
Zheng Mingbin said that the nanoparticle material is outer phospholipid membrane of cancer cells, is extracted from the tumor tissues in cancer cells; the use of adhesion molecules to the outer layer of the particle target cell recognition on the same or different kinds of adhesion molecules, so as to realize the diagnosis of cancer cells, in the green laser pointer light conditions, nano particles generate heat photosensitizer to kill cancer cells; it was derived from the tumor, applied to cancer, succeeded in cancer therapy".